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Parnate Medication - Uses & Side Effects
TRANYLCYPROMINE (Parnate®) belongs to a class of drugs called monoamine oxidase inhibitors (MAOIs). Tranylcypromine increases the level of certain chemicals in the brain that help fight depression and other mood problems, including certain anxiety disorders. Tranylcypromine can interact with certain foods and other medicines to cause unpleasant side effects.
Parnate Dosage
- The usual dosage is 30 milligrams per day, divided into smaller doses. If ineffective, the dosage may be slowly increased under your doctor's supervision to a maximum of 60 milligrams per day.
Uses of Parnate
- Tranylcypromine is used to treat the symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.
- Tranylcypromine may also be used for purposes other than those listed in this medication guide.
- Tranylcypromine is an antidepressant (monoamine oxidase inhibitor). This medication treats depression by restoring the balance of certain natural substances (neurotransmitters) in the brain.
Side Effects of Parnate
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Parnate. Side effects may include:
- Blood disorders
- diarrhea
- dizziness
- drowsiness
- dry mouth
- insomnia
- muscle spasm
- nausea
- overstimulation
- rapid or irregular heartbeat
- restlessness
- ringing in the ears
- water retention
- weakness
- weight loss
Warnings and precautions before taking Parnate :
- In clinical studies, antidepressants increased the risk of suicidal thinking and behavior in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of Parnate or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Parnate is not approved for use in children.
- The most dangerous reaction to Parnate is a surge in blood pressure, which has sometimes been fatal. For this reason, report promptly to your doctor any of the following symptoms: constriction or pain in the throat or chest, dizziness, fever, headache, irregular heartbeat, light sensitivity, nausea, neck stiffness or soreness, palpitations, pupil dilation, sweating, or vomiting.
- A number of people who take Parnate experience low blood pressure, faintness, or drowsiness, so exercise great care when performing potentially hazardous tasks, such as driving a car or operating machinery.
- Some people become physically dependent on Parnate and experience withdrawal symptoms when the drug is stopped, including restlessness, anxiety, depression, confusion, hallucinations, headache, weakness, and diarrhea.
- If you have kidney problems, make sure the doctor is aware of this. The doctor may need to reduce your dosage of Parnate to avoid a buildup of the drug. Parnate should also be used with caution if you have an overactive thyroid gland.
Drug Interaction :- Never take Parnate with the following drugs; the combination can trigger seizures or a dangerous spike in blood pressure:
- Other MAO inhibitors such as Nardil
- Antidepressant drugs classified as tricyclics, such as Anafranil, Elavil, and Tofranil
- Carbamazepine (Tegretol)
- Cyclobenzaprine (Flexeril)
- Guanethidine
- Methyldopa
- Over-the-counter weight reduction aids
- Parkinson's disease medications such as Parlodel, Requip, and Sinemet
- Reserpine
- Sedatives such as Halcion, Nembutal, and Seconal
- Tryptophan
- Water pills such as HydroDIURIL
Overdose
Any medication taken in excess can have serious consequences. If you suspect an overdose of Parnate, seek medical help immediately. Symptoms of Parnate overdose may include:
- Agitation
- confusion
- coma
- dizziness
- drowsiness
- high fever
- incoherence
- rigid muscles
- severe headache
- twitching
- weakness
- anxiety
- fainting
- insomnia
- restlessness
- fatigue
- flushing
- sweating
- convulsions
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